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Fig. 4. Injection of NO donor NOC-18 prior to KA injection exacerbates excitotoxicity in wild-type mice. Wild-type mice were injected with either PBS or 1 mM NOC-18 immediately prior to injection with the indicated concentrations of KA or with PBS and sacrificed at day 1. Cresyl Violet staining indicated that 1 mM NOC-18 alone is not toxic to neurons. However, injection of 1 mM NOC-18 immediately prior to injection of low doses of KA potentiates neuronal cell death. n=6 per treatment.





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