spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online July 25, 2006

Journal of Cell Science 119, 1503e (2006)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Arrestin' news: protein relocates to nucleus...


Figure 1

Several signalling molecules originally thought to be restricted to the cytoplasm are now known to move into the nucleus under certain circumstances. Eva Neuhaus and co-workers now add ß-arrestin 2 to this list and suggest that it might help to regulate gene expression during fertilization (see p. 3047). ß-arrestins uncouple activated G-protein-coupled receptors (GPCRs) from their G protein partners and mediate the endocytosis of the GPCRs - among other functions. The authors show that ß-arrestin 2 appears in the nucleus of human spermatozoa after stimulation of the GPCR hOR17-4. This olfactory receptor, which promotes the chemotaxis of human sperm, colocalizes with ß-arrestin 2 in the midpiece of mature human spermatozoa. The authors report that, on reaching the nucleus, ß-arrestin can regulate transcription, possibly by modifying the nuclear localization of specific transcription factors. They therefore propose that nuclear translocation of ß-arrestins may be a hitherto unrecognized way in which GPCRs regulate gene transcription.


Related articles in JCS:

Novel function of ß-arrestin2 in the nucleus of mature spermatozoa
Eva M. Neuhaus, Anastasia Mashukova, Jon Barbour, Dirk Wolters, and Hanns Hatt
JCS 2006 119: 3047-3056. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content