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First published online June 20, 2006

Journal of Cell Science 119, 1304e (2006)
© The Company of Biologists Limited
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In this issue

Fusion factors supplied by rafts

Lipid rafts, membrane microdomains rich in cholesterol and sphingomyelin, seem to regulate the Ca2+ sensitivity and rate of Ca2+-triggered fusion of membranes during exocytosis. One hypothesis is that they do this by localizing `efficiency' factors such as Ca2+ sensors. On p. 2688, Tatiana Rogasevskaia and Jens Coorssen provide support for this idea by showing that the integrity of sphingomyelin-enriched microdomains determines the efficiency of Ca2+-triggered membrane fusion. In fully primed, release-ready cortical vesicles from sea-urchin eggs, cholesterol contributes to both the efficiency of fusion and the vesicles' fundamental ability to fuse. Rogasevskaia and Coorssen now show that the disruption of rafts with sphingomyelinase inhibits the Ca2+ sensitivity and kinetics of vesicle fusion but not their intrinsic ability to fuse. These data, the authors conclude, are consistent with the existence of a minimal native fusion machine that has a low intrinsic Ca2+ sensitivity that can be enhanced by recruitment and organization of efficiency components by microdomains.


Related articles in JCS:

Sphingomyelin-enriched microdomains define the efficiency of native Ca2+-triggered membrane fusion
Tatiana Rogasevskaia and Jens R. Coorssen
JCS 2006 119: 2688-2694. [Abstract] [Full Text]  




This Article
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