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First published online May 24, 2006

Journal of Cell Science 119, 1103e (2006)
© The Company of Biologists Limited
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In this issue

Haemoxygenase and CO: regulators for respiration


Figure 1

The effects of carbon monoxide (CO) on whole organisms are well known - too much can cause unconsciousness or death. Its effects on individual cells are much less clear, but on p. 2291 Salvador Moncada and colleagues fill in some of the blanks. They report that endogenously produced CO, like nitric oxide (NO), inhibits cellular respiration by interacting with mitochondrial cytochrome c oxidase - particularly during hypoxia. Endogenous NO regulates cellular oxygen consumption in many physiological and pathophysiological situations. The authors now show that endogenously produced CO also inhibits cellular respiration in human kidney cells. This effect, they report, is enhanced under hypoxic conditions. Furthermore, haemoxygenase - the enzyme that makes CO - can operate at much lower oxygen concentrations than NO synthase. Consequently, suggest the authors, although endogenously produced NO and CO might both contribute to inhibition of cellular respiration, endogenously produced CO might be largely responsible for this in hypoxic tissues - for example, after a stroke or in ischaemic heart disease.


Related articles in JCS:

Inhibition of cellular respiration by endogenously produced carbon monoxide
Gabriela D'Amico, Francis Lam, Thilo Hagen, and Salvador Moncada
JCS 2006 119: 2291-2298. [Abstract] [Full Text]  




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