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First published online April 5, 2005

Journal of Cell Science 118, 802e (2005)
© The Company of Biologists Limited
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In this issue

Yeast microtubules run out of Amo


Microtubules play a central role in cell division and cell polarity in eukaryotic cells. Fission yeast represents a useful model system for studies of their regulation, since its cytoskeleton is highly organized and dynamic. Interphase fission yeast cells contain 2-5 longitudinal bundles of microtubules, and these grow from the cell centre to its ends, where they undergo catastrophe. Mercedes Pardo and Paul Nurse have now characterized Amo1, a nucleoporin-like protein whose overexpression causes microtubules to bundle on one side of the cell (see p. 1705). Amo1 localizes to the nuclear rim but does not overlap with nuclear pore complex components. The phenotype of amo1{Delta} cells indicates that Amo1 helps to regulate microtubule growth, cell-end termination and cell polarity. These observations, together with the localization of Amo1, suggest that the interplay between the nucleus and microtubules is important for the regulation of microtubule dynamics. However, Pardo and Nurse find no evidence that the loading of factors affecting microtubule dynamics is defective in amo1{Delta} cells; so how Amo1 regulates microtubule dynamics remains unclear.


Related articles in JCS:

The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast
Mercedes Pardo and Paul Nurse
JCS 2005 118: 1705-1714. [Abstract] [Full Text]  




This Article
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