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Fig. 3. Cancer therapy that does not kill tumor stem cells may provide gratifying initial results but ultimately result in recurrence. Conventional therapies target proliferating, terminally differentiated cells may leave tumor stem cells, which could lead to recurrence. Ideally, tumor stem cell therapies would specifically target tumor stem cells. Used alone, they might lead to tumor regression, but not dissolve tumor bulk, leading to questions regarding response rates and potentially untreated tumor-related symptoms. Combining conventional therapy with treatment targeting tumor stem cells may effectively eliminate both tumor bulk and tumor stem cells that might otherwise lead to recurrence.





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