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First published online May 12, 2005

Journal of Cell Science 118, 1005e (2005)
© The Company of Biologists Limited
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In this issue

Actin' roles in yeast apoptosis


Apoptosis is usually studied in multicellular organisms but unicellular yeast cells also apoptose. Here, apoptosis is thought to enhance colony survival by removing old cells during environmental stress (e.g. when nutrients are limiting). On p. 2119, Campbell Gourlay and Kathryn Ayscough describe how actin dynamics link environmental stress responses to apoptosis in baker's yeast. Previous data indicate that the reduction in actin dynamics produced by actin mutations generates an apoptotic phenotype that includes increased levels of oxidative stress. The authors now identify the actin-regulatory proteins Sla1p and End3p and the ubiquitin ligase Rsp5p as components of the upstream regulatory pathway that controls actin-mediated apoptosis. In addition, they show that overexpression of the cAMP phosphodiesterase PDE2 – a negative regulator of the Ras/cAMP signalling pathway that links the stress response to nutrient availability – suppresses both the actin defects and the oxidative-stress phenotype seen in cells lacking End3p. This provides the first evidence for a physiological link between nutritional sensing and actin-mediated apoptosis in yeast.


Related articles in JCS:

Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast
Campbell W. Gourlay and Kathryn R. Ayscough
JCS 2005 118: 2119-2132. [Abstract] [Full Text]  




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