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First published online November 10, 2004

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Nuclear translation on trial

In prokaryotes, transcription and translation are coupled. In eukaryotes, by contrast, the spatial separation of the two processes prevents this: mRNA is transcribed in the nucleus, exported to the cytoplasm and only then translated. But are things that simple? Recent work has hinted that some translation might actually take place in the nucleus. Moreover, ribosome components have cropped up in nuclear preparations, and there are indications that surveillance mechanisms that detect faulty mRNAs in the nucleus rely on transcription-translation coupling. Set against this evidence are numerous studies that argue against nuclear translation. So what are we to believe? In a hypothesis on p. 5713, Peter Cook and coworkers put the case for the defence.

Related articles in JCS:

The case for nuclear translation

Francisco J. Iborra, Dean A. Jackson, and Peter R. Cook
JCS 2004 117: 5713-5720. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content