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First published online August 17, 2004

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Sticking together: p120 catenin's developmental role

Modulation of cell-cell adhesion underlies the many morphogenetic movements that occur during development. p120 catenin (p120) is a potential regulator of the adhesive strength of cadherins, important cell-cell adhesion molecules. Kris Vleminckx and colleagues now report that p120 is required for the morphogenetic movements that form the eyes and the craniofacial skeleton in Xenopus (see p. 4325). The authors show that Xenopus p120 is strongly expressed in the eye vesicles and branchial arches, both highly morphogenetic tissues. Then, they describe how injection of p120 morpholinos into the embryonic region destined to become the head, or injection of constructs that generate E-cadherin mutants unable to bind p120, impairs optic vesicle evagination and cranial neural crest cell migration into the branchial arches. Thus, unlike in invertebrates, in vertebrates p120 crucially regulates morphogenetic movement in the anterior region of the early embryo, probably by modifying cadherin activity.

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p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus

Malgorzata Ciesiolka, Mieke Delvaeye, Griet Van Imschoot, Veerle Verschuere, Pierre McCrea, Frans van Roy, and Kris Vleminckx
JCS 2004 117: 4325-4339. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content