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First published online May 28, 2004

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NO, NO and thrice NO

Endogenously produced nitric oxide (NO) has numerous physiological roles. It is generated by three enzymes: eNOS, nNOS and iNOS. NO produced in endothelia by eNOS regulates blood vessel dilation by targeting vascular smooth muscle cells; NO produced in neurons by nNOS regulates synaptic signalling and plasticity in the brain; and NO produced in large quantities by iNOS in cells of the innate immune system can kill fungal and bacterial pathogens and inhibits viral replication. The Cell Science at a Glance section of JCS is currently featuring a series of contributions covering the various roles of NO. In the second of these, Imran Mungrue and David Bredt tackle NO generated by nNOS (see p. 2627 + poster).

Related articles in JCS:

nNOS at a glance: implications for brain and brawn

Imran N. Mungrue and David S. Bredt
JCS 2004 117: 2627-2629. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content