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First published online August 13, 2003

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Synaptic vesicles - the great debates

Release of neurotransmitters by synaptic vesicles is central to synaptic transmission. The mechanisms by which these vesicles are filled, release their contents into the synapse and ultimately are recycled are important examples of membrane trafficking. Despite intensive research, however, the roles of the key players in the synaptic vesicle cycle - SNAREs, the Rab3 GTPase, vacuolar H⁺ ATPases (V-ATPases) and the SNARE-binding protein UNC-18 - remain controversial. In Cell Science at a Glance (p. 3661 + poster), Robby Weimer and Erik Jorgensen survey current models for the functions of these proteins in priming, docking, fusion and recycling of synaptic vesicles, summarising the evidence for their involvement at each stage.

Related articles in JCS:

Controversies in synaptic vesicle exocytosis

Robby M. Weimer and Erik M. Jorgensen
JCS 2003 116: 3661-3666. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content