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Fig. 8. Production of adhesion-related proteins in the cornea. Western blot analysis of E-cadherin (A), desmoglein (B), ß-catenin (C), {gamma}-catenin (D) and paxillin (E) derived from wild-type and SEY (+/–) corneal extracts from 6-week-old mice. Levels of desmoglein and ß- and {gamma}-catenin are reduced approximately eight, two and two times, respectively. A Ponceau-stained protein blot (F) from wild-type and SEY (+/–) corneal extracts shows equivalent amounts of protein. Immunolocalization of E-cadherin shows similar cell membrane staining in wild-type (G) and SEY (+/–) corneas (H) corneas. Abbreviations: ALDH3, aldehyde dehydrogenase 3; c, epithelium; MW, molecular weight markers; WT, wild type.





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