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Fig. 1. Generation of conditional Pig-a-knockout female mice by Cre/loxP recombination. Male mice carrying a ZP3-Cre transgene and wild-type Pig-a alleles were mated with females carrying an eGFP-GPI transgene and two Pig-aflox alleles. The eGFP-GPI transgene provides expression of eGFP-GPI as a marker to confirm loss of GPI-APs in knockout animals. ZP3-Cre:eGFP-GPI:Pig-a f/y males derived from this mating were crossed with eGFP-GPI:Pig-a f/f females to generate conditional knockout females with the genotype ZP3-Cre:eGFP-GPI:Pig-a f/f.





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