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Fig. 2. TSG-6 properties and functions. TSG-6 binds specifically to GAGs, including HA, C4S and heparin and to the proteoglycan aggrecan. It also interacts, both covalently and non-covalently, with I{alpha}I: covalent complexes may be involved in crosslinking HA chains, whereas non-covalent interactions potentiate the anti-plasmin activity of I{alpha}I. TSG-6 has been implicated in cell proliferation, the inhibition of neutrophil migration and the regulation of CD44. The mechanisms of these activities remain to be elucidated.





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