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Filopodia are conduits for melanosome transfer to keratinocytes

Glynis Scott, Sonya Leopardi, Stacey Printup and Brian C. Madden

QuickTime Video JPEG Image

Movie 1

Movies of a melanocyte dendrite with prominent filopodia.





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Movie 2

Movies of a melanocyte dendrite in which a filopodia makes contact with a keratinocyte membrane. A melanosome can be seen moving along the filopodia towards the keratinocyte.





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Movie 3

Movies of a melanocyte dendrite in which a filopodia makes multiple contacts with a keratinocyte membrane. Melanosomes can be seen moving along the filopodia towards the keratinocyte.


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Movie 4

Five minutes after treatment of cells with nocodazole, melanosomes have redistributed towards the melanocyte cell body, leaving a dendrite, which appears empty. Filopodia were not affected by nocodazole treatment.



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Movie 5

A movie of a melanocyte dendrite in contact with a keratinocyte. A filopodia arising from the lateral aspect of the dendrite is either attached or inserted into the keratinocyte membrane. A string of melanosomes (approximately six melanosomes) moves in single file toward the keratinocyte.







This Article
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