Fig. 2. At higher RGD cluster sizes, WT NR6 cell adhesion is reinforced in response to the increased detachment force in the range of 70-150 pN/cell, followed by a monotonic decrease and a density-dependent plateau at higher forces. When cluster size remains unchanged, cell adhesion strength increases with increasing average RGD density. Each graph illustrates adhesion profiles obtained from substrates presenting RGD peptides in various cluster sizes: (A) 5.4 RGD/cluster; (B) 3.6 RGD/cluster; (C) 1.7 RGD/cluster.

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