Fig. 10. The nuclear localization of p120ctn isoforms correlates with their capacity to induce the branching phenotype. The isoforms 1A (A), 2A (D) and 3A (F) as well as the deletion construct 2ANS (E) localized equally in the cytoplasm and in the cell nucleus. In addition to the prominent signal at the cell-cell adhesion junctions, filopodial structures are starting to emerge. Isoforms 1AB (B), 4A (H) and the deletion construct 3AAK (G) were excluded from the nucleus but localized to the cytoplasm. The C-terminally truncated 1A, 1X, showed nuclear localization but was not sufficient for the induction of branching cellular phenotype (C). Bar, 50 µm.

Return to article