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Journal of Cell Science 115, e505-e505 (2002)
© 2002 The Company of Biologists Limited

In this issue

Nuclear diacylglycerol and PKC-ßII import at G2/M (p. 983)


In G2/M phase, PKC-ßII translocates to the nucleus, where it is proposed to stimulate disassembly of the nuclear lamina by phosphorylating lamin B1. But PKC-ßII is just one of a host of cellular PKC isoforms. How do cells selectively translocate PKC-ßII? Janet Lord and co-workers have addressed this question by analysing the levels of potential PKC-activating lipids in nuclei during the cell cycle; they used centrifugal elutriation to isolate cells at different stages of the cell cycle and thereby avoid the use of cell cycle inhibitors. The authors find that nuclear translocation of PKC-ßII correlates with an increase in the levels of nuclear diacylglycerol - in particular the tetraunsaturated species 1-stearoyl, 2-arachidonyl glycerol (SAG). They show that SAG potently activates PKC-{alpha} and PKC-ßII but not the novel isoform PKC-{delta}. Lord and co-workers propose that generation of nuclear SAG at G2/M facilitates association of PKC-ßII with the nuclear membrane - perhaps as part of a general mechanism for differential control of PKC signalling by distinct forms of diacylglycerol.


Related articles in JCS:

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-ßII at G2/M
Elizabeth M. Deacon, Trevor R. Pettitt, Paul Webb, Timothy Cross, Hema Chahal, Michael J. O. Wakelam, and Janet M. Lord
JCS 2002 115: 983-989. [Abstract] [Full Text]  




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