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Journal of Cell Science 115, e304-e304 (2002)
© 2002 The Company of Biologists Limited

In this issue

Caveolae: transporters for Ca2+ signalling machinery (p. 475)


Caveolae are membrane domains thought to compartmentalize and/or sequester signalling molecules. In endothelial cells, they appear to be associated with initiation of Ca2+ waves. Following binding of ATP to Gq-coupled cell surface receptors, Ca2+ is released from the ER at sites associated with a subset of plasma membrane caveolae. Richard Anderson and co-workers have analysed the role of caveolae in Ca2+ signalling in migrating endothelial cells. They show that cell migration induced by wounding or shear stress causes caveolae (but not clathrin-coated pits) to move to the trailing edge of the cell. The exciting finding is that this is accompanied by movement of both Ca2+-release sites and the G protein G{alpha}q to the same location. Caveolae might thus act not only as containers for the Ca2+ signalling machinery but also as vehicles for its transport. If caveolae indeed function as transporters for signalling molecules, they could play a critical role in cell polarity.


Related articles in JCS:

Sites of Ca2+ wave initiation move with caveolae to the trailing edge of migrating cells
Masashi Isshiki, Joji Ando, Kimiko Yamamoto, Toshiro Fujita, Yunshu Ying, and Richard G. W. Anderson
JCS 2002 115: 475-484. [Abstract] [Full Text]  




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