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Fig. 3. Scatter of RET/GFR{alpha}1-MDCK cells in response to GDNF. Untreated cells (std med) remain as well-bounded islands that are separated by clear spaces (arrows). On addition of GDNF, the inter-island spaces are invaded by motile cells. Incubation of the cells in 30 mM chlorate for the preceding 24 hours and during the scattering period, or incubation in 0.3 U/ml heparanase III for the preceding 2 hours and during the scattering period, greatly reduces this effect of GDNF and clear spaces remain (arrows) although the edges of the islands do still lose their smoothness compared to controls.





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