Fig. 1. Alignment of deduced amino acid sequences of ARL5, ARLs and ARF1. Sources of sequences are: hARF1 (Bobak et al., 1989); hARL1 (Zhang et al., 1995); hARL2 (Clark et al., 1993); hARL3 (Cavenagh et al., 1994); hARL4 (Lin et al., 2000); hARL5 [this study (Smith et al., 1995)]; mARL5 (this study). Amino acids identical in at least five of the seven sequences compose the consensus sequence shown at the top. Underlines indicate consensus sequences for GTP binding and hydrolysis. Double underline indicates consensus sequences for nuclear localization signal. Black boxes indicate amino acids identical in hARL4, hARL5 and mARL5 sequences. Gray boxes indicate amino acids similar in hARL4, hARL5 and mARL5 sequences.

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