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Fig. 3. Neurons expressing a phorbol-ester-binding-deficient Munc13-1 are
completely insensitive to phorbol esters. Time course of phorbol-ester effects
on evoked EPSCs in hippocampal neurons from wild-type-like Munc13-2-deficient
mice (black squares, n=6) and
Munc13-2-deficient/Munc13-1H567K double mutant mice (grey circles,
n=6). Application of PDBU (1 µM) is indicated by the black bar.
EPSCs were evoked at 0.2 Hz and normalised to the initial amplitude. Error
bars indicate s.e.m.
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