Fig. 2. The developing Drosophila eye primordium: A paradigm for studying how HH controls the cell cycle? Differentiating photoreceptor cells, labelled with antibodies that recognise a neuron-specific protein (BLUE), express and secrete HH (GREEN), as revealed by GFP expression from a hh reporter transgene. Cells immediately anterior to these differentiating photoreceptors enter a synchronised S phase followed by mitosis (small arrows) in response to this source of HH activity. These mitotic cells are marked with antibodies to phospho-histone (RED), which also labels randomly dividing cells anteriorly in the developing primordium (long arrows).

Return to article