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Fig. 3. Involvement of Tec kinases in TCR signaling. The Tec kinases (represented here by Itk) are part of a signaling complex nucleated by LAT and SLP76 that is critical for the activation of PLC-{gamma}, Ca2+ mobilization, MAPK activation, as well as for downstream cytoskeletal rearrangements and transcriptional regulation. The red boxes represent phosphorylated ITAMs on the intracellular tails of the invariant TCR chains. Red circles represent actin. PIP2, PtdIns(4,5)P2; PIP3, PtdIns(3,4,5)P3.





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