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Journal of Cell Science 115, e1102-e1102 (2002)
© 2002 The Company of Biologists Limited

In this issue

Nucleolar assembly


Like the nucleus itself, the nucleolus - the cell's ribosome factory - is dismantled in preparation for cell division. Its reassembly begins in telophase, and the compartment is fully formed by early G1 phase. What drives this process, and how is it regulated? In a Commentary on p. 2265, Danièle Hernandez-Verdun and co-workers review work that has shed light on the mechanics of nucleolar assembly and its coordination with the cell cycle. Studies some years ago suggested that assembly is driven by activation of the Pol I transcriptional machinery, the rRNA-processing machinery being recruited by the pre-ribosomal RNAs (pre-rRNAs) transcribed. More recent experiments, however, indicate that things are more complex. For example, inhibition of Pol I during the assembly process has revealed that partly processed rRNAs remain during mitosis and recruit processing components such as fibrillarin to forming nucleoli independently of Pol I transcription. Furthermore, whereas Pol I transcription is regulated by the mitotic kinase Cdc2 (CDK1), recruitment of the processing machinery seems to depend on another, unidentified, CDK.


Related articles in JCS:

Emerging concepts of nucleolar assembly
Danièle Hernandez-Verdun, Pascal Roussel, and Jeannine Gébrane-Younès
JCS 2002 115: 2265-2270. [Abstract] [Full Text]  




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