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First published online January 10, 2008
doi: 10.1242/10.1242/jcs.021253

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How polarity shapes the destiny of T cells

Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 2002, Australia and Center for MicroPhotonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Victoria 3122, Australia

View larger version (31K): [in this window] [in a new window]   Fig. 1. T cells have two poles and an axis of polarity. (A) The axis of polarity during (i) migration, (ii) antigen presentation and T-cell cytotoxicity, and (iii) receptor capping. (B) Model whereby a competing ligand (depicted as cell-surface associated, but it could also be a soluble ligand, such as a chemokine) recruits the MTOC and dictates the axis of polarity, preventing appropriate polarisation towards the APC (the grey arrow depicts the axis that fails to generate by the APC. (C) How the axis of polarity generated during antigen presentation can regulate the mitotic axis and the asymmetric localisation of proteins during cell division. It is possible that the APC could be replaced by other triggers of T-cell polarity to dictate asymmetric cell division.

View larger version (18K): [in this window] [in a new window]   Fig. 2. Activities that might be influenced by asymmetric cell division in lymphocytes. Lymphocytes (pale green) divide while attached to a spatial cue (grey) that dictates the axis of division. In each case, the polarity network (grey circles) and perhaps direct interactions with the polarising cue, regulate the asymmetric distribution of cell fate determinants (coloured circles), such that they are segregated differently into the two daughter cells of naive CD8+ or CD4+ T cells responding to APCs (A,B), and perhaps in thymocytes responding to thymic epithelial cells (TECs) (C).