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First published online April 23, 2007
doi: 10.1242/10.1242/jcs.005975

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Epithelial tight junctions, gene expression and nucleo-junctional interplay

Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK

View larger version (114K): [in this window] [in a new window]   Fig. 1. Morphology of the epithelial junctional complex. Shown is an electron micrograph of an ultrathin section of Epon-embedded MDCK cells. The positions of tight junctions (TJ) and desmosomes (D) are indicated. Note, the close contacts between the neighbouring plasma membranes at the tight junctions. Reprinted from Huber et al. (Huber et al., 1998) with permission from Karger.

View larger version (30K): [in this window] [in a new window]   Fig. 2. Tight-junction-associated NACos and their interaction partners. If known, the functional consequences of interactions between the proteins are indicated. Arrows indicate processes that can be regulated by a particular protein. Continuous arrows indicate functional interactions that have been demonstrated to be influenced by tight junctions; dashed arrows indicate instances where it is not known whether junctional association is functionally relevant.

View larger version (33K): [in this window] [in a new window]   Fig. 3. Dual-localisation of ZONAB to the nucleus and epithelial junctions in proliferating (A) versus non-proliferating, confluent MDCK cells (B) fixed either directly or after heat shock. (A) The distributions of ZONAB (red) and ZO-1 (green) were visualised by double immunofluorescence; shown is a confocal section. (B) Epifluorescence images of ZONAB staining before and after heat shock [for experimental details, see Balda and Matter (Balda and Matter, 2000) and Tsapara et al. (Tsapara et al., 2006)].