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First published online July 2, 2007
doi: 10.1242/10.1242/jcs.011080

Journal of Cell Science 120, 2295-2299 (2007)
Published by The Company of Biologists 2007
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Unconventional secretion: an extracellular trap for export of fibroblast growth factor 2

Walter Nickel

Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany


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  		Fig. 1. Schematic model for FGF-2 secretion. Nonclassical FGF-2 export from mammalian cells can be dissected into three steps. (1) Plasma membrane targeting; (2) membrane translocation; and (3) extracellular trapping by binding to HSPGs. FGF-2 membrane translocation does not depend on ATP hydrolysis or a membrane potential but rather is a diffusion-controlled process. Net transport to the extracellular space is established by a molecular trap consisting of HSPGs, the heparan sulfate binding sites for FGF-2 being located close to the extracellular membrane surface.

 




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