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First published online July 12, 2005
doi: 10.1242/10.1242/jcs.02505

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The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity

Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan

View larger version (19K): [in a new window]   Fig. 1. A model for ERK-mediated signal transduction. (A) If various extracellular stimuli elicit a single mode of ERK activity, the ERK activation should lead to a single cellular response. (B) If several regulators control the duration, magnitude and/or compartmentalization of ERK activity upon stimulation, the resulting different modes of ERK activity can regulate multiple cellular responses.

View larger version (28K): [in a new window]   Fig. 2. Schematic representation of regulatory mechanisms for ERK activation and cellular responses.