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First published online 7 December 2004
doi: 10.1242/jcs.01597

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Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA

View larger version (10K): [in a new window]   Fig. 1. Experimental protocol for transplant experiments. The numbers under the lines represent the host age when animals were experimentally manipulated. c, clear the fat pad; t, transplant of TM10 fragments; DMBA, administration of DMBA; t(2), transplant from group 2; t(WG.3,4), transplant whole gland from group 3 or 4.

View larger version (19K): [in a new window]   Fig. 2. The timecourse of tumorigenesis from transplanted TM10 mammary preneoplastic outgrowths. The mice were palpated weekly for tumors. (A) Groups 1 and 2; shows the effect of a single dose of DMBA on mammary tumorigenesis in TM10 mouse mammary outgrowth line. (B) Groups 3 and 4; shows the effect of DMBA treatment of stroma on mammary tumorigenesis in TM10 mouse mammary outgrowth line. UNT, untreated; DMBA, DMBA-treated; (C) Groups 5 and 6; shows mammary tumorigenesis of DMBA-treated TM10 mammary outgrowths in untreated and DMBA-treated stroma. DMBA/UNT, DMBA-treated epithelial cells/untreated host; DMBA/DMBA, DMBA-treated epithelial cells/DMBA-treated host. (D) Groups 7 and 8; shows tumorigenesis in the whole mammary gland transplants into untreated hosts. UNT/UNT UNT; untreated epithelial cells/untreated host and transplanted as whole mammary gland into untreated host; UNT/DMBA UNT, untreated epithelial cells/DMBA-treated host and transplanted as whole mammary gland into untreated host.