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doi: 10.1242/10.1242/jcs.00460

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Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast

Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Rd, Kansas City, MO 64112, USA

View larger version (27K): [in a new window]   Fig. 1. Mechanisms of signal integration. (A) Convergence of nutritional and cell type control signals on regulation of the IME1 gene. The different signals shown at the top of the figure act through different regulatory elements of the IME1 gene. (B) Convergence of nutritional signal on regulation of the IME2 gene through the URS1 regulatory element.

View larger version (20K): [in a new window]   Fig. 2. Working model for the signal network that controls meiotic initiation in S. cerevisiae. The three principal nutritional signals required to initiate meiosis are shown in boxes. The diagram shows some of the signal transduction pathways that control meiotic initiation and examples of where these pathways are connected (see text for details). The names of the proteins are abbreviated without the final `p' for brevity (e.g. Snf1 rather than Snf1p).