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Biological roles and mechanistic actions of co-repressor complexes

¹ Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 920393-0648, USA

View larger version (29K): [in a new window]   Fig. 1. (A) Transcriptional repression by nuclear receptors is regulated by recruitment of the co-repressors N-CoR and/or SMRT. (B) The domains of N-CoR/SMRT. Repression domains (RI, RII, RIII) and SANT domains (A and B) are indicated, as are interaction domains for HDACs, nuclear receptors (I and II) and other transcription factors. (C) N-CoR—SMRT compexes. Biochemical purification techniques have revealed several different complexes recruited by N-CoR and/or SMRT (Jones et al., 2001; Li et al., 2000; Underhill et al., 2000; Wen et al., 2000; Guenther et al., 2000).

View larger version (29K): [in a new window]   Fig. 2. Other HDAC-containing co-repressor complexes identified by biochemical purification, including the Sin 3-SAP (Sin-associated proteins) complex (Zhang et al., 1997; Zhang et al., 1998c), the NURD (nucleosome remodeling and histone deacetylation) complex (Tong et al., 1998; Xue et al., 1998; Zhang et al., 1998b; Zhang et al., 1999), a NURD-related HDAC-complex (Humphrey et al., 2001) and a CoREST-HDAC complex (Humphrey et al., 2001; You et al., 2001). Dashed outlines indicate the molecule that was used to purify each complex.