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TAF_II250

a transcription toolbox

¹ National Institutes of Health, National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch, Building 18T, Room 101, Bethesda, MD 20892, USA
² Zentrum fur Molekulare Biologie der Universtät Heidelberg (ZMBH), Im Neunheimer Feld 282, Heidelberg 69120, Germany
^* Author for correspondence (e-mail: f.sauer{at}mail.zmbh.uni-heidelberg.de )

View larger version (14K): [in a new window]   Fig. 1. A schematic diagram of metazoan TAFII250. Locations of enzymatic domains (N-terminal kinase domain (NTK), C-terminal kinase domain (CTK), histone acetyltransferase domain (HAT), and ubiquitin-activating/conjugating domain (E1/E2)) and bromodomains (Bromo) are indicated within the linear TAFII250 protein. Substrates for the enzymatic activities are indicated above the TAFII250 protein, and interacting proteins are indicated below the protein. Substrates and interacting partners are abbreviated as follows: TFIIA (A), TFIIE (E), TFIIF (F), TATA-binding protein (TBP), retinoblastoma protein (RB), HIV Tat (TAT) and TFIIF (RAP74).

View larger version (37K): [in a new window]   Fig. 2. A four-step model for how TAFII250 contributes to transcriptional activation. In each step, the panel on the left depicts the general event and the panel on the right depicts the specific contribution of TAFII250 to the event. Activators are denoted by a red circle labeled A; TFIIA is denoted by a green oval labeled A; TFIIE is denoted by a green circle labeled E; TFIIF is denoted by a blue circle labeled F; histones are labeled H1, H2A, H2B, H3 or H4; and TFIID is denoted by a collection of objects labeled 250, 150 and TBP. The balance of the general transcription machinery, which is not specifically identified, is indicated by a collection of objects labeled GTM.