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Quarterly Journal of Microscopical Science, Vol s3-95, 17-22, Copyright © 1954 by Company of Biologists

The Effect of Phenylthiourea on Pigmentation by Melanin in the Developing Frog, Eleutherodactylus martinicensis

NORMAN MILLOTT 1 and W. GARDNER LYNN 1

1 Department of Zoology, University College of the West Indies, Jamaica

The black pigment cells in the skin, iris, and retina of Eleutherodactylus martinicensis (Tschudi) are melanophores. Under the influence of c o 1 per cent, phenylthiourea the melanin disappears in about 84 hours at laboratory temperatures. After administration of the substance for 5 days, discontinuance of treatment is followed by return of the pigment within 72 hours, to an extent at least equal to that normally attained in untreated controls. The stages of disappearance and reappearance of this pigment have been studied in the gross embryo, skin, iris, and retina, as well as in individual melanophores.






© The Company of Biologists Ltd 1954