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Quarterly Journal of Microscopical Science, Vol s3-90, 309-315, Copyright © 1949 by Company of Biologists

Aldehydes in relation to Absorption of Fat from the Intestine and Metabolism of Fat in the Liver

J. F. DANIELLI 1

1 Chester Beatty Research Institute, Royal Cancer Hospital, Fulham Road, London, S.W. 3

1. During the absorption of fatty acids or of fat from the intestine of mice and rats, no intervention of long-chain aldehydes occurs.

2. When fat is being metabolized or synthesized in the liver of mice and rats aldehydes are prominent. Each fat droplet being metabolized is surrounded by a spherical shell containing aldehyde and basiphilic material.

3. The results indicate that long-chain aldehydes or their derivatives are essential intermediates in the metabolism of fatty acids, and suggest that the acetals of these aldehydes are intermediates in the synthesis of glycerides and phospholipines, &c.






© The Company of Biologists Ltd 1949