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Quarterly Journal of Microscopical Science, Vol s3-88, 45-53, Copyright © 1947 by Company of Biologists

The Action of Diethylstilboestrol on the Prostatic Epithelium of the Mouse

E. S. HORNING D.Sc.1

1 Imperial Cancer Research Fund Laboratories

1. The cellular changes in the prostatic epithelium of an inbred strain of mice (R III), following short periods of treatment with large doses of oestrogen, are described.

2. The Golgi apparatus in the cells of the prostatic epithelium affords a precise indication of the degree of stimulation induced by oestrogenic substances.

3. Specific morphological changes in the Golgi substance occur in the epithelium of the anterior lobe of the prostate after 8 days' treatment. Similar changes, following longer periods of treatment, also occur in the dorsal and ventral lobes.

4. Withdrawal of oestrogenic stimulation after 20 days' treatment with relatively large doses is followed by a return of the prostatic epithelium and the Golgi apparatus to their normal condition in 21 days.






© The Company of Biologists Ltd 1947