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Quarterly Journal of Microscopical Science, Vol s3-88, 27-37, Copyright © 1947 by Company of Biologists

The Behaviour of Mammalian Skin Epithelium under Strictly Anaerobic Conditions

P. B. MEDAWAR 1

1 Department of Zoology and Comparative Anatomy, Oxford

1. The viability of skin epithelium subjected to various experimental treatments may be tested by transplantation technique.

2. Skin can survive for upwards of a week in serum at body temperature in the total absence of atmospheric or dissolved oxygen.

3. Neither cellular movement nor cell division can take place in skin epithelium under anaerobic conditions.

4. The survival of skin epithelium depends upon the integrity of a mechanism, presumably glycolysis, that is put out of action by iodoacetate at a concentration of the order of 10-4 molar.






© The Company of Biologists Ltd 1947