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Journal of Cell Science, Vol 92, Issue 3 361-370, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Expression of nuclear lamins in mammalian somatic cells lacking cytoplasmic intermediate filament proteins

M Paulin-Levasseur, A Scherbarth, G Giese, K Roser, W Bohn and P Traub
Max-Planck-Institut fur Zellbiologie, Ladenburg/Heidelberg, Federal Republic of Germany.

Using immunofluorescence and immunoblotting techniques, we have examined the composition of the nuclear lamina in murine plasmacytoma cells, MPC-11, exposed to the phorbol ester TPA as well as in two cell lines devoid of cytoplasmic intermediate filament proteins, the human adrenal cortex carcinoma-derived cells SW-13 and the clone C6-M-D4 derived from the rat glial cell line C6. Our results show that the inhibition of proliferation and the induction of vimentin synthesis observed in TPA-treated MPC-11 populations are not paralleled by changes in the lamin complement of these cells, which contain lamin B but lack lamins A and C. Furthermore, the analysis performed on SW-13 and C6-M-D4 cell lines clearly demonstrates that mammalian somatic cells display considerable variations in lamin expression and indicates that lamin B may be the only lamin species constitutively expressed in mammalian cells.


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© The Company of Biologists Ltd 1989