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Journal of Cell Science, Vol 91, Issue 4 549-553, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Serum from partially hepatectomized rats induces primary hepatocytes to enter S phase: a role for prostaglandins?

P Little, GG Skouteris, MG Ord and LA Stocken
Department of Biochemistry, University of Oxford, UK.

Serum obtained from partially hepatectomized rats 1, 3 or 24 h after operation was more effective in stimulating DNA synthesis in primary adult rat hepatocytes than serum from sham-operated rats; exposure to the serum for 2 h was sufficient to promote growth. Serum from the partially hepatectomized rats contained elevated levels of PGE2 and PGF2 alpha; it promoted hepatocytes to release prostaglandins into their culture medium. Growth-promoting effects of the serum and its capacity to elicit prostaglandin release into the culture medium were inhibited by 0.1 mM-indomethacin or 1 mM-aspirin. 0.1 mM-indomethacin also prevented DNA synthesis if the inhibitor were added 4 h after growth had been initiated by serum from partially hepatectomized rats, suggesting that prostaglandins continue to be important for the maintenance of hepatocyte growth for at least 6 h.


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© The Company of Biologists Ltd 1988