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Journal of Cell Science, Vol 91, Issue 1 139-144, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Initiation of the cortical reaction in hamster and sheep oocytes in response to inositol trisphosphate

DG Cran, RM Moor and RF Irvine
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.

Microinjection of inositol 1,4,5-triphosphate into sheep and hamster oocytes induces secretion of cortical granules in a dose-dependent manner. In the sheep, this effect is strongly pH-dependent with minimal exocytosis taking place at pH 6.8 but a full cortical reaction occurring at pH8.0. Exocytosis in the hamster is also affected by the pH of the external medium but to a lesser extent. Injection of GTP gamma S also induces exocytosis in both species but is more effective in the hamster. It is suggested that inositol metabolism stimulated by sperm-egg interaction with a GTP-binding protein may be part of the mechanism leading to cortical granule exocytosis and that this may be modulated by the external pH.


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© The Company of Biologists Ltd 1988