spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Doroszewski, J.
Right arrow Articles by Kiwala, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doroszewski, J.
Right arrow Articles by Kiwala, A.

Journal of Cell Science, Vol 90, Issue 2 335-340, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Adhesion and locomotion of granulocytes under flow conditions

J Doroszewski and A Kiwala
Department of Biophysics and Biomathematics, Medical Center of Postgraduate Education, Warszawa, Poland.

The aim of this study was to compare the strength of the surface adhesion of migrating human granulocytes and the main parameters of their locomotion under the influence of various external forces. The strength of adhesion of granulocytes moving in a quiescent medium was studied by detaching them gravitationally from the plane surface situated above them. In these conditions the force of adhesion is of the same order of magnitude as the gravitational force operating upon the cells. The locomotion characteristics of granulocytes migrating on a surface below them are similar to those observed during their movement on a surface above. When the granulocytes migrate with the medium flowing past them, they are not detached from the surface even by relatively great shearing forces (10 and 100 times greater in comparison with the gravitational force) and the locomotion parameters are only slightly modified. The results show that granulocytes are able to migrate in a similar manner when they are subjected to various external forces.




© The Company of Biologists Ltd 1988