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Journal of Cell Science, Vol 80, Issue 1 281-298, Copyright © 1986 by Company of Biologists

JOURNAL ARTICLES

Shape control in the human red cell

L Backman

When the human red cell consumes its ATP, the cell loses its discoid character in favour of a spiculated and eventually a spherical form. This discocyte-echinocyte transformation parallels both degradation of phosphatidylinositol 4,5-bisphosphate and phosphatidic acid but not dephosphorylation of cytoskeletal proteins. Dephosphorylation of both spectrin and band 3 lags behind metabolic crenation. Exogenous vanadate accelerates both shape changes and lipid dephosphorylation in a parallel manner during metabolic depletion. In contrast to its effect on lipids, vanadate reduces the rate of protein dephosphorylation. These observations strongly support a shape control mechanism in the red cell, based on phosphoinositide metabolism and compatible with a bilayer-couple model.


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S. Tuvia, S. Levin, A. Bitler, and R. Korenstein
Mechanical Fluctuations of the Membrane-Skeleton Are Dependent on F-Actin ATPase in Human Erythrocytes
J. Cell Biol., June 29, 1998; 141(7): 1551 - 1561.
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© The Company of Biologists Ltd 1986