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Journal of Cell Science, Vol 75, Issue 1 149-163, Copyright © 1985 by Company of Biologists

JOURNAL ARTICLES

X chromosome inactivation during induced differentiation of a female mouse embryonal carcinoma cell line

GD Paterno and MW McBurney

P10 is a line of embryonal carcinoma cells with a euploid female karyotype. By making use of variant alleles of X-linked genes and of cytogenetic procedures, we have previously shown that the P10 cells have two genetically active X chromosomes. We show here that P10 cells rapidly differentiate into a cell type resembling extraembryonic endoderm when cultured in the presence of retinoic acid. This differentiation is accompanied by X chromosome inactivation as determined by the appearance of a late-replicating X chromosome. Analysis of the X-linked variant alleles indicated that the P10-derived endoderm did not preferentially inactivate paternally derived X chromosomes. This result is in contrast to the situation in normal extraembryonic endoderm, and suggests that the X inactivation process in differentiating P10 cultures resembles that which occurs in normal embryonic rather than extraembryonic tissues.


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 DevelopmentHome page
T Tada, M Tada, and N Takagi
X chromosome retains the memory of its parental origin in murine embryonic stem cells
Development, January 11, 1993; 119(3): 813 - 821.
[Abstract] [PDF]


© The Company of Biologists Ltd 1985