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Journal of Cell Science, Vol 72, Issue 1 213-226, Copyright © 1984 by Company of Biologists

JOURNAL ARTICLES

DNA replication and repair in Tilapia cells. I. The effect of ultraviolet radiation

FH Yew and LM Chang

The effect of ultraviolet radiation on a cell line established from the warm water fish Tilapia has been assessed by measuring the rate of DNA synthesis, excision repair, post-replication repair and cell survival. The cells tolerate ultraviolet radiation better than mammalian cells with respect to DNA synthesis, post-replication repair and cell survival. They are also efficient in excision repair, which in other fish cell lines has been found to be at a low level or absent. Their response to the inhibitors hydroxyurea and 1-beta-D-arabinofuranosylcytosine is less sensitive than that of other cell lines, yet the cells seem to have very small pools of DNA precursor.




© The Company of Biologists Ltd 1984