spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dylewski, D. P.
Right arrow Articles by Keenan, T. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dylewski, D. P.
Right arrow Articles by Keenan, T. W.

Journal of Cell Science, Vol 72, Issue 1 185-193, Copyright © 1984 by Company of Biologists

JOURNAL ARTICLES

Centrioles in the mammary epithelium of the rat

DP Dylewski and TW Keenan

Through serial thin-section analysis of rat mammary epithelial cells, the number of centrioles per cell and their intracellular location were determined. In all developmental stages (e.g. virginal, pregnant, lactation, involution), each epithelial cell contained a single centriole that was located in the apical region. Centrioles were 200-220 (mean = 210) nm in transverse section, and exhibited the typical 9 X 3 'pinwheel' configuration of microtubules. In longitudinal section, centrioles were 330-380 (mean = 360) nm in length. Each centriole was surrounded by a homogeneous pericentriolar matrix. During mitosis in pregnant animals, centrioles were paired at the nuclear poles and oriented at right angles (90 degrees) to each other. At the completion of mitosis a single diplosome (pair of centrioles) was associated with each interphase nucleus. Because all postmitotic cells contained only a single centriole, it was assumed that one of the two diplosomal centrioles had disintegrated. There appeared to be a correlation between centriole location and cell polarity. When centrioles were located near the apical plasma membrane, epithelial cells exhibited polarity. However, when centrioles were associated with the nuclear poles during mitosis, epithelial cells were typically apolar. These observations suggest that centrioles may function as determinants in cell polarity.


This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
K. A. Wojtal, D. Hoekstra, and S. C.D. van IJzendoorn
Anchoring of Protein Kinase A-Regulatory Subunit II{alpha} to Subapically Positioned Centrosomes Mediates Apical Bile Canalicular Lumen Development in Response to Oncostatin M but Not cAMP
Mol. Biol. Cell, July 1, 2007; 18(7): 2745 - 2754.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1984