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Journal of Cell Science, Vol 7, 49-54, Copyright © 1970 by Company of Biologists

Submitted on November 24, 1969

Kinetochore Ultrastructure in Vincristine-Treated Mammalian Cells

L. J. JOURNEY 1 and AUDREY WHALEY 1

1 St. Jude Children's Research Hospital and Department of Anatomy, University of Tennessee Medical Units, Memphis, Tennessee 38101, U.S.A.

The ultrastructure of chromosomes from tissue culture cells blocked in division with vin-cristine sulphate or colchicine was examined. Kinetochores had a distinctive morphology consisting of trilaminar dense plates closely applied to the chromosomes. In longitudinal sections, kinetochores appeared as separate plates attached to opposite sides of the chromosomes. In transverse sections of some prometaphase chromosomes, however, the kinetochore resembled an incomplete ring-like structure encircling the chromatid pair. These observations indicate that sister kinetochores may be continuous during early stages of their formation.

Submitted on November 24, 1969






© The Company of Biologists Ltd 1970