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Journal of Cell Science, Vol 66, Issue 1 189-194, Copyright © 1984 by Company of Biologists


JOURNAL ARTICLES

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue

DA Hume, JF Loutit and S Gordon

The macrophage-specific antigen F4/80 has been localized in adult mouse bone and connective tissue. F4/80 positive cells form the centre of haemopoietic islands, line the periosteal and subendosteal bone surfaces and are a major component of connective tissue and the synovial membrane (presumptive type A cells). F4/80 is absent from fibroblasts, chondrocytes, osteoblasts, osteocytes, osteoclasts and a subpopulation of synovial lining cells (presumptive type B cells).


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© The Company of Biologists Ltd 1984