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Journal of Cell Science, Vol 6, 821-841, Copyright © 1970 by Company of Biologists

Submitted on October 20, 1969

Seasonal Changes in Secretory Granules and Crystalloid Inclusions of Bat Thyroid Parafollicular Cells

E. A. NUNEZ 1, R. P. GOULD 2, and S. J. HOLT 3

1 Department of Radiology, Cornell University Medical School, New York, New York 10021, U.S.A.
2 Department of Anatomy, Middlesex Hospital Medical School, London, W.1, England
3 Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London, W.1, England

Parafollicular cells of active Autumn bats sometimes contain many large dense secretory granules (diameter 1-2µm) enclosed within ribosome-studded membranes. At the same time, parafollicular cells containing small granules were often characterized by the presence of slender crystalloid rods, up to several microns in length.

Parafollicular cells with large granules become depleted of them following exposure of nonhibernating bats to cold (4°C) for 12-48h. This treatment causes no change in the cells containing small granules, although partial degranulation in such cells was seen in early hibernating (November) bats.

On the basis of these and previous studies it is suggested that the two types of granules in bat parafollicular cells have different fates during the animal's annual cycle of physiological activity.

Submitted on October 20, 1969






© The Company of Biologists Ltd 1970