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Journal of Cell Science, Vol 4, 583-591, Copyright © 1969 by Company of Biologists

Submitted on August 6, 1968

Nuclear Ultrastructure of the Transforming Lymphocyte during Inhibition of Deoxyribonucleic Acid Synthesis with Hydroxyurea

GILLIAN R. MILNER 1

1 Department of Medicine, University of Cambridge England

The pattern of decondensation of heterochromatin in the transforming lymphocyte was found to be unaffected by hydroxyurea although DNA synthesis, which normally accompanies the latter part of this decondensation, was greArticleTitley inhibited. It is suggested that metabolic inhibition of DNA synthesis may result in atypical sites of DNA synthesis when the inhibitor is removed, since such sites are normally partly governed by an ordered sequence of decondensation of heterochromatin.

Submitted on August 6, 1968







© The Company of Biologists Ltd 1969