|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 4, 353-367, Copyright © 1969 by Company of Biologists
Submitted on May 18, 1968
1 M.R.C. Experimental Virus Research Unit, Institute of Virology, University of Glasgow, Scotland
2 M.R.C. Experimental Virus Research Unit, Institute of Virology, University of Glasgow, Scotland; Institute of Biochemistry, University of Glasgow, Scotland
Cells of a genetic variant of the hamster fibroblast line BHK 21 which lack inosinic pyrophosphorylase activity (IPP- cells) and therefore cannot normally incorporate [3H]hypoxanthine were grown in mixed culture with cells of BHK 21 sublines which have inosinic pyrophosphorylase activity (IPP+ cells). If not in contact with IPP+ cells, IPP- cells do not incorporate added [3H]hypoxanthine into nucleic acid. IPP+ cells always do incorporate [3H]hypoxanthine and IPP- cells when in direct or indirect contact with IPP+ cells also incorporate the isotope. Cell to cell contact appears to be essential for this gain of a metabolic function by IPP- cells.
The possible molecular basis and general implications of the phenomenon are discussed.
Submitted on May 18, 1968
This article has been cited by other articles:
|
|
 |
|
  K.-L. Ang, L. Takura Shenje, L. Srinivasan, and M. Galinanes Repair of the damaged heart by bone marrow cells: from experimental evidence to clinical hope. Ann. Thorac. Surg., October 1, 2006; 82(4): 1549 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Muramatsu, M. Iwai, T. Morikawa, S. Tanaka, T. Mori, Y. Harada, and T. Okanoue Influence of transfection with connexin 26 gene on malignant potential of human hepatoma cells Carcinogenesis, February 1, 2002; 23(2): 351 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mesnil and H. Yamasaki Bystander Effect in Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Cancer Gene Therapy: Role of Gap-junctional Intercellular Communication1 Cancer Res., August 1, 2000; 60(15): 3989 - 3999. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Chow and H. Rubin Coculturing diverse clonal populations prevents the early-stage neoplastic progression that occurs in the separate clones PNAS, January 4, 2000; 97(1): 174 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Hobbie, D. Kingsley, K. Kozarsky, R. Jackman, and M Krieger Restoration of LDL receptor activity in mutant cells by intercellular junctional communication Science, January 2, 1987; 235(4784): 69 - 73. [Abstract] [PDF]
|
|
|
|
|
|
M. Wade, J. Trosko, and M Schindler A fluorescence photobleaching assay of gap junction-mediated communication between human cells Science, April 25, 1986; 232(4749): 525 - 528. [Abstract] [PDF]
|
|
|
|
|
|
L. Yotti, C. Chang, and J. Trosko Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter Science, November 30, 1979; 206(4422): 1089 - 1091. [Abstract] [PDF]
|
|
|
|
|
|
E Kohen, C Kohen, B Thorell, D. Mintz, and A Rabinovitch Intercellular communication in pancreatic islet monolayer cultures: a microfluorometric study Science, May 25, 1979; 204(4395): 862 - 865. [Abstract] [PDF]
|
|
